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Chemical Structure : GMI-1070
Catalog No.: PC-61286Not For Human Use, Lab Use Only.
GMI-1070 (Rivipansel, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively.
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GMI-1070 (Rivipansel, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively.
GMI-1070 predominantly inhibits E-selectin-mediated adhesion and dramatically inhibits sRBC-leukocyte interactions, leading to improved microcirculatory blood flow and improved survival.
GMI-1070 is a valuable novel therapeutic intervention for acute sickle cell crises.
| M.Wt | 1447.421 | |
| Formula | C58H74N6O31S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang J, et al. Blood. 2010 Sep 9;116(10):1779-86.
2. Azab AK, et al. Blood. 2012 Feb 9;119(6):1468-78.
3. Wun T, et al. PLoS One. 2014 Jul 2;9(7):e101301.
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