GMI-1070 |CAS:927881-99-0 Probechem Biochemicals

Chemical Structure : GMI-1070

GMI-1070 (Rivipansel, PF-06460031)

Catalog No.: PC-61286Not For Human Use, Lab Use Only.

GMI-1070 (Rivipansel, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively.

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Biological Activity

GMI-1070 (Rivipansel, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively.
GMI-1070 predominantly inhibits E-selectin-mediated adhesion and dramatically inhibits sRBC-leukocyte interactions, leading to improved microcirculatory blood flow and improved survival.
GMI-1070 is a valuable novel therapeutic intervention for acute sickle cell crises.

Physicochemical Properties

M.Wt	1447.421
Formula	C58H74N6O31S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-[[13-[(1R,3R,4R,5S)-3-[[2-O-Benzoyl-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-b-D-galactopyranosyl]oxy]-4-[(6-deoxy-a-L-galactopyranosyl)oxy]-5-[[(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl]amino]cyclohexyl]-1,8,13-trioxo-3,6-dioxa-9,12-diazatride

References

1. Chang J, et al. Blood. 2010 Sep 9;116(10):1779-86.

2. Azab AK, et al. Blood. 2012 Feb 9;119(6):1468-78.

3. Wun T, et al. PLoS One. 2014 Jul 2;9(7):e101301.

GMI-1070 (Rivipansel, PF-06460031)

Biological Activity

Physicochemical Properties

References

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