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GMI-1215

Chemical Structure : GMI-1215

CAS No.:

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GMI-1215 (GMI1215)

Catalog No.: PC-61283Not For Human Use, Lab Use Only.

A dual inhibitor of E selectin and CXCR4 with IC50 of 4.1 uM and 30 nM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A dual inhibitor of E selectin and CXCR4 with IC50 of 4.1 uM and 30 nM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice; inhibits E-selectin and SDF-1 mediated chemotaxis in a transwell-based assay, effectively mobilizes leukemia from the marrow and reduces the bone marrow burden of AML in combination with chemotherapy.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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