GMI-1271 |CAS:1914993-95-5 Probechem Biochemicals

Chemical Structure : GMI-1271

GMI-1271 (GMI1271, Uproleselan sodium)

Catalog No.: PC-61285Not For Human Use, Lab Use Only.

GMI-1271 (Uproleselan sodium) is a specific glycomimetic E-Selectin antagonist with Kd of 0.46 uM, IC50 of 1.75 uM.

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Biological Activity

GMI-1271 (Uproleselan sodium) is a specific glycomimetic E-Selectin antagonist with Kd of 0.46 uM, IC50 of 1.75 uM.
GMI-1271 weakly inhibits L-selectin (IC50=2.9 uM) and >10 uM for P-selectin.
GMI-1271 not only mobilizes AML cells out of protective niches but also blocks NF-kB activation and prevents this E-selectin-mediated chemoresistance, thereby enhancing the therapeutic effects of standard chemotherapy; also overcomes MM metastasis and chemoresistance.

Physicochemical Properties

M.Wt	1326.508
Formula	C60H108N3NaO27
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxaoctatriacontanamide, N-[2-[[[(1R,3R,4R,5S)-3-[[2-(acetylamino)-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-2-deoxy-b-D-galactopyranosyl]oxy]-4-[(6-deoxy-a-L-galactopyranosyl)oxy]-5-ethylcyclohexyl]carbonyl]amino]ethyl

References

1. Price TT, et al. Mol Cell Oncol. 2016 Jul 26;4(4):e1214771.

2. Culmer DL, et al. Thromb Haemost. 2017 Jun 2;117(6):1171-1181.

3. Natoni A, et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.123.

4. Dutta P, et al. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1802-8.

GMI-1271 (GMI1271, Uproleselan sodium)

Biological Activity

Physicochemical Properties

References

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