Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GMI-1271
Catalog No.: PC-61285Not For Human Use, Lab Use Only.
GMI-1271 (Uproleselan sodium) is a specific glycomimetic E-Selectin antagonist with Kd of 0.46 uM, IC50 of 1.75 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GMI-1271 (Uproleselan sodium) is a specific glycomimetic E-Selectin antagonist with Kd of 0.46 uM, IC50 of 1.75 uM.
GMI-1271 weakly inhibits L-selectin (IC50=2.9 uM) and >10 uM for P-selectin.
GMI-1271 not only mobilizes AML cells out of protective niches but also blocks NF-kB activation and prevents this E-selectin-mediated chemoresistance, thereby enhancing the therapeutic effects of standard chemotherapy; also overcomes MM metastasis and chemoresistance.
| M.Wt | 1326.508 | |
| Formula | C60H108N3NaO27 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Price TT, et al. Mol Cell Oncol. 2016 Jul 26;4(4):e1214771.
2. Culmer DL, et al. Thromb Haemost. 2017 Jun 2;117(6):1171-1181.
3. Natoni A, et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.123.
4. Dutta P, et al. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1802-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
