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Chemical Structure : GMX-1777 chloride
Catalog No.: PC-60007Not For Human Use, Lab Use Only.
GMX-1777 chloride (Teglarinad) is the water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.
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GMX-1777 chloride (Teglarinad) is the water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.
GMX-1777 shows anticancer activity in clinical trials, can be used in combination with other drugs to treat malignant melanoma.
| M.Wt | 672.601 | |
| Formula | C30H43Cl2N5O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in H2O |
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1. Watson M, et al. Mol Cell Biol. 2009 Nov;29(21):5872-88.
2. Beauparlant P, et al. Anticancer Drugs. 2009 Jun;20(5):346-54.
3. Kato H, et al. Clin Cancer Res. 2010 Feb 1;16(3):898-911.
4. Chan M, et al. Cancer Res. 2014 Nov 1;74(21):5948-54.
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