GMX-1777 chloride (Teglarinad) | NAMPT inhibitor

Chemical Structure : GMX-1777 chloride

CAS No.: 432037-57-5

GMX-1777 chloride (GMX1777 chloride, Teglarinad, EB-1627)

Catalog No.: PC-60007Not For Human Use, Lab Use Only.

GMX-1777 chloride (Teglarinad) is the water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.

Packing	Price	Stock
5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

GMX-1777 chloride (Teglarinad) is the water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.
GMX-1777 shows anticancer activity in clinical trials, can be used in combination with other drugs to treat malignant melanoma.

Physicochemical Properties

M.Wt	672.601
Formula	C30H43Cl2N5O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	100 mM in H2O
Chemical Name/SMILES	[4-[[N'-[6-(4-chlorophenoxy)hexyl]-N-cyanocarbamimidoyl]amino]pyridin-1-ium-1-yl]methyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonate chloride

References

1. Watson M, et al. Mol Cell Biol. 2009 Nov;29(21):5872-88.

2. Beauparlant P, et al. Anticancer Drugs. 2009 Jun;20(5):346-54.

3. Kato H, et al. Clin Cancer Res. 2010 Feb 1;16(3):898-911.

4. Chan M, et al. Cancer Res. 2014 Nov 1;74(21):5948-54.

GMX-1777 chloride (GMX1777 chloride, Teglarinad, EB-1627)

Biological Activity

Physicochemical Properties

References

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