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GNE-0439

Chemical Structure : GNE-0439

CAS No.: 1241902-40-8

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GNE-0439 (GNE0439)

Catalog No.: PC-62325Not For Human Use, Lab Use Only.

GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM).
GNE-0439 also inhibits mutant N1742K channels with IC50 of 0.37 uM in membrane potential assays, but not mutation of R1608A (IC50>50 uM).
GNE-0439 is unique compared with known selective VSD4 binders such as the arylsulfonamides (GX-936 and PF-05089771).

Physicochemical Properties

M.Wt 345.483
Formula C21H31NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(4-propylcyclohexyl)benzoyl)-L-valine

References

1. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.

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