GNE-0723 | GluN2A PAM | Probechem Biochemicals

Chemical Structure : GNE-0723

Catalog No.: PC-20369Not For Human Use, Lab Use Only.

GNE-0723 (GNE0723) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 21 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GNE-0723 (GNE0723) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 21 nM.

M.Wt	467.77
Formula	C16H8ClF6N5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-2-(7-((5-Chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-5-oxo-2-(trifluoromethyl)-5H-thiazolo[3,2-a]pyrimidin-3-yl)cyclopropanecarbonitrile

1. Volgraf M, et al. J Med Chem. 2016 Mar 24;59(6):2760-79.