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Chemical Structure : GNE-1858
CAS No.: 2680616-96-8
Catalog No.: PC-72304Not For Human Use, Lab Use Only.
GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay.
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|---|---|---|---|
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GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay.
GNE-1858 potently inhibits all three HPK1 kinase domain variants under investigation in a dose-dependent manner (IC50=4.5 nM against the residual kinase activity of HPK1-SA).
| M.Wt | 428.492 | |
| Formula | C21H26F2N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)- |
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1. Wu P, et al. Structure. 2019 Jan 2;27(1):125-133.e4.
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