Chemical Structure : GNE-1858
CAS No.:
2680616-96-8
GNE-1858
(GNE1858)
Catalog No. : PC-72304Not For Human Use, Lab Use Only.
GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7230401
Biological Activity
GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay.
Physicochemical Properties
M.Wt
428.492
Formula
C21H26F2N8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1H-Pyrazolo[4,3-c]pyridin-6-amine, N-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(3-pyrrolidinyl)-4-pyrimidinyl]-1-(1-methylethyl)-
References
1. Wu P, et al. Structure.
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