Catalog No.: PC-62720Not For Human Use, Lab Use Only.
GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively, shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3).
GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively.
GNE-2861 shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3).
GNE-2861 decreases tumor cell migration and invasion in triple-negative breast cancer cell lines, perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells.
