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Chemical Structure : GNE-2861
CAS No.: 1394121-05-1
Catalog No.: PC-62720Not For Human Use, Lab Use Only.
GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively, shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively.
GNE-2861 shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3).
GNE-2861 decreases tumor cell migration and invasion in triple-negative breast cancer cell lines, perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells.
| M.Wt | 406.49 | |
| Formula | C22H26N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2-(1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-1,3-benzodiazol-6-yl)ethynyl)cyclohexan-1-ol |
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1. Staben ST, et al. J Med Chem. 2014 Feb 13;57(3):1033-45.
2. Zhuang T, et al. Oncotarget. 2015 Dec 22;6(41):43853-68.
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