GNE-3419 | GluN2A PAM | Probechem Biochemicals

Chemical Structure : GNE-3419

Catalog No.: PC-25185Not For Human Use, Lab Use Only.

GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D.

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Biological Activity

GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D.

M.Wt	300.38
Formula	C15H16N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((ethyl(phenyl)amino)methyl)-2-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

1. Volgraf M, et al. J Med Chem. 2016 Mar 24;59(6):2760-79.

2. Tzu-Ming Wang, et al. Neuropharmacology. 2017 Jul 15:121:204-218.

3. David H Hackos, et al. Neuron. 2016 Mar 2;89(5):983-99.