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GNE-477

Chemical Structure : GNE-477

CAS No.: 1032754-81-6

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GNE-477 (GNE477;GNE 477)

Catalog No.: PC-42796Not For Human Use, Lab Use Only.

GNE-477 is a potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR.

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10 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNE-477 is a potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Ki of 21 nM for mTOR.
GNE-477 inhibits MCF7.1 cell proliferation with EC50 of 143 nM.
GNE-477 displays desirable pharmacokinetic properties, exhibits stasis in a PC3 tumor growth inhibition study.

Physicochemical Properties

M.Wt 504.6288
Formula C21H28N8O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 9.2 mg/mL
Chemical Name/SMILES

2-Pyrimidinamine, 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-

References

1. Heffron TP, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11.

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