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GNE-493

Chemical Structure : GNE-493

CAS No.: 1033735-94-2

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GNE-493 (GNE493;GNE 493)

Catalog No.: PC-42708Not For Human Use, Lab Use Only.

GNE-493 (GNE493) is a potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.

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10 mg $188 In stock
25 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNE-493 (GNE493) is a potent, selective dual pan-PI3K/mTOR inhibitor with IC50 of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR.
GNE-493 (GNE493) displays 100-fold selective for PI3Kα over Aurora A, MLK1, Syk.
GNE-493 (GNE493) has good PK profiles, and are efficacious in xenograft models; orally available.

Physicochemical Properties

M.Wt 372.4447
Formula C17H20N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 45 mg/mL
Chemical Name/SMILES

Thieno[3,2-d]pyrimidine-6-methanol, 2-(2-amino-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-

References

1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.

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