GNE-5729 | GluN2A PAM | Probechem Biochemicals

Chemical Structure : GNE-5729

Catalog No.: PC-20370Not For Human Use, Lab Use Only.

GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM.

M.Wt	428.20
Formula	C17H10Cl2F3N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-2-(7-chloro-2-((5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile

1. Elisia Villemure, et al. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.