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Chemical Structure : GNE-617
CAS No.: 1362154-70-8
Catalog No.: PC-38786Not For Human Use, Lab Use Only.
GNE-617 is a potent, selective, cellularly active NAMPT inhibitor with IC50 of 5 nM, inhibits multiple cancer cell lines (U251, HT1080, PC3, MiaPaCa2, and HCT116 lines) with IC50 of <10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNE-617 is a potent, selective, cellularly active NAMPT inhibitor with IC50 of 5 nM, inhibits multiple cancer cell lines (U251, HT1080, PC3, MiaPaCa2, and HCT116 lines) with IC50 of <10 nM.
GNE-617 displayed acceptable mouse PK properties (F = 41%, CL = 52.4 mL/min/kg), and exhibited robust efficacy in a U251 mouse xenograft model.
| M.Wt | 427.43 | |
| Formula | C21H15F2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[[4-[(3,5-Difluorophenyl)sulfonyl]phenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide |
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1. Yauch RL, et al. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.
2. O'Brien T, et al. Neoplasia. 2013 Dec;15(12):1314-29.
3. Zheng X, et al. J Med Chem 2013;56:6413–33.
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