GNE-9815 | pan-RAF inhibitor | Probechem Biochemicals

Chemical Structure : GNE-9815

CAS No.: 2729996-45-4

Catalog No.: PC-72469Not For Human Use, Lab Use Only.

GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively.

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10 mg	$248	In stock
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50 mg	$728	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively.

GNE-9815 displays clean kinase selectivity against a panel of 223 kinases (no inhibition > 70% at a concentration of 0.1 μM) besides RAF kinases).

GNE-9815 demonstrates synergistic activity in KRAS mutant A549 and HCT116 cancer cells in combination with the MEK inhibitor cobimetinib.

GNE-9815 in combination with the MEK inhibitor cobimetinib demonstrated synergistic MAPK pathway modulation in an HCT116 xenograft mouse model.

M.Wt	455.493
Formula	C26H22FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-cyanopropan-2-yl)-N-(2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl)benzamide

1. Malcolm P Huestis, et al. ACS Med Chem Lett. 2021 Apr 21;12(5):791-797.