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Chemical Structure : GNF-2-deg
Catalog No.: PC-22559Not For Human Use, Lab Use Only.
GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
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GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
GNF-2-deg exhibits increased antiviral potency compared to the parental E inhibitor GNF-2, with EC90 WT value of 3.5 uM, and 13.11 uM respectively.
GNF-2-deg has a dual mode of action: inhibition of E's function in viral entry and blocking of viral particle production due to a targeted protein degradation (TPD) mechanism.
GNF-2-deg exhibits broad-spectrum activity against multiple flaviviruses, with antiviral EC90 values consistently in the single-digit micromolar across ZIKV, JEV, and WNV Kunjin.
| M.Wt | 762.70 | |
| Formula | C37H33F3N6O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu HY, et al. Nat Commun. 2024 Jun 19;15(1):5179.
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