Chemical Structure : GNF-2-deg
CAS No.:
GNF-2-deg
Catalog No.: PC-22559Not For Human Use, Lab Use Only.
GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
GNF-2-deg exhibits increased antiviral potency compared to the parental E inhibitor GNF-2, with EC90 WT value of 3.5 uM, and 13.11 uM respectively.
GNF-2-deg has a dual mode of action: inhibition of E's function in viral entry and blocking of viral particle production due to a targeted protein degradation (TPD) mechanism.
GNF-2-deg exhibits broad-spectrum activity against multiple flaviviruses, with antiviral EC90 values consistently in the single-digit micromolar across ZIKV, JEV, and WNV Kunjin.
Physicochemical Properties
|
M.Wt
|
762.70
|
|
Formula
|
C37H33F3N6O9
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethoxy)ethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide
|
References
1. Liu HY, et al. Nat Commun. 2024 Jun 19;15(1):5179.
Contact Us
sales@probechem.com
