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GNF-2

Chemical Structure : GNF-2

CAS No.: 778270-11-4

GNF-2 (GNF 2, GNF2)

Catalog No.: PC-42783Not For Human Use, Lab Use Only.

GNF-2 is a potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells.

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Biological Activity

GNF-2 is a potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells.
GNF-2 causes growth inhibition of Bcr-Abl positive cell lines with IC50s of 273 nM (K562) and 268 nM (SUP-B15).
GNF-2 inhibits mutant Bcr-Abl E255V, Y253H cell growth.

Physicochemical Properties

M.Wt 374.3166
Formula C18H13F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 45 mg/mL

Chemical Name/SMILES

Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-

References

1. Adrián FJ, et al. Nat Chem Biol. 2006 Feb;2(2):95-102.

2. Choi Y, et al. J Biol Chem. 2009 Oct 16;284(42):29005-14.

3. Clark MJ, et al. Cell Chem Biol. 2016 Apr 21;23(4):443-52.

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