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Chemical Structure : GNF-2
CAS No.: 778270-11-4
Catalog No.: PC-42783Not For Human Use, Lab Use Only.
GNF-2 is a potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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GNF-2 is a potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells.
GNF-2 causes growth inhibition of Bcr-Abl positive cell lines with IC50s of 273 nM (K562) and 268 nM (SUP-B15).
GNF-2 inhibits mutant Bcr-Abl E255V, Y253H cell growth.
| M.Wt | 374.3166 | |
| Formula | C18H13F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]- |
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1. Adrián FJ, et al. Nat Chem Biol. 2006 Feb;2(2):95-102.
2. Choi Y, et al. J Biol Chem. 2009 Oct 16;284(42):29005-14.
3. Clark MJ, et al. Cell Chem Biol. 2016 Apr 21;23(4):443-52.
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