Chemical Structure : GNF-2
CAS No.:
778270-11-4
GNF-2
(GNF 2, GNF2)
Catalog No.: PC-42783Not For Human Use, Lab Use Only.
GNF-2 is a potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells.
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| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | | Get quote | |
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Purity & Documentation Purity:
>98% (HPLC)
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Biological Activity
GNF-2 is a potent, allosteric, non-ATP competitive Bcr-Abl inhibitor that shows exclusive antiproliferative activity toward Bcr-abl-transformed cells.
GNF-2 causes growth inhibition of Bcr-Abl positive cell lines with IC50s of 273 nM (K562) and 268 nM (SUP-B15).
GNF-2 inhibits mutant Bcr-Abl E255V, Y253H cell growth.
Physicochemical Properties
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M.Wt
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374.3166
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Formula
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C18H13F3N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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DMSO: ≥ 45 mg/mL
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Chemical Name/SMILES
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Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-
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References
1. Adrián FJ, et al. Nat Chem Biol. 2006 Feb;2(2):95-102.
2. Choi Y, et al. J Biol Chem. 2009 Oct 16;284(42):29005-14.
3. Clark MJ, et al. Cell Chem Biol. 2016 Apr 21;23(4):443-52.
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