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GNF-351

Chemical Structure : GNF-351

CAS No.: 1227634-69-6

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GNF-351 (GNF 351;GNF351)

Catalog No.: PC-60390Not For Human Use, Lab Use Only.

GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential.

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5 mg $88 In stock
10 mg $138 In stock
25 mg $228 In stock
50 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential.
GNF-351 antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibits both DRE-dependent and -independent activity.
GNF-351 decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.

Physicochemical Properties

M.Wt 411.5
Formula C24H25N7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine

References

1. Smith KJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):318-27.

2. Fang ZZ, et al. Br J Pharmacol. 2014 Apr;171(7):1735-46.

3. DiNatale BC, et al. Mol Cancer Res. 2012 Oct;10(10):1369-79.

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