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Chemical Structure : GNF-351
CAS No.: 1227634-69-6
Catalog No.: PC-60390Not For Human Use, Lab Use Only.
GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential.
GNF-351 antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibits both DRE-dependent and -independent activity.
GNF-351 decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.
| M.Wt | 411.5 | |
| Formula | C24H25N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine |
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1. Smith KJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):318-27.
2. Fang ZZ, et al. Br J Pharmacol. 2014 Apr;171(7):1735-46.
3. DiNatale BC, et al. Mol Cancer Res. 2012 Oct;10(10):1369-79.
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