GNF-7 |CAS:839706-07-9 Probechem Biochemicals

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Chemical Structure : GNF-7

CAS No.: 839706-07-9

GNF-7 (GNF 7;GNF7)

Catalog No.: PC-42749Not For Human Use, Lab Use Only.

A potent and selective type-II kinase inhibitor of Bcr-Abl.

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10 mg	$120	In stock
25 mg	$240	In stock
50 mg	$432	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent and selective type-II kinase inhibitor of Bcr-Abl; inhibits wt Bcr-Abl/T315I Bcr-Abl (IC50< 5 nM) and Bcr-Abl mutants such as G250E, Q252H, Y253H, E255K, E255V, F317L, and M351T in biochemical and cellular assays; displays in vivo efficacy against T315I-Bcr-Abl in xenograft mouse model.

Physicochemical Properties

M.Wt	547.5311
Formula	C28H24F3N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Benzamide, N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

References

1. Choi HG, et al. J Med Chem. 2010 Aug 12;53(15):5439-48.

2. Nonami A, et al. Blood. 2015 May 14;125(20):3133-43.

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GNF-7 (GNF 7;GNF7)

Biological Activity

Physicochemical Properties

References

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