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Chemical Structure : GNF-7
CAS No.: 839706-07-9
Catalog No.: PC-42749Not For Human Use, Lab Use Only.
A potent and selective type-II kinase inhibitor of Bcr-Abl.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $240 | In stock | |
| 50 mg | $432 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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A potent and selective type-II kinase inhibitor of Bcr-Abl; inhibits wt Bcr-Abl/T315I Bcr-Abl (IC50< 5 nM) and Bcr-Abl mutants such as G250E, Q252H, Y253H, E255K, E255V, F317L, and M351T in biochemical and cellular assays; displays in vivo efficacy against T315I-Bcr-Abl in xenograft mouse model.
| M.Wt | 547.5311 | |
| Formula | C28H24F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- |
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1. Choi HG, et al. J Med Chem. 2010 Aug 12;53(15):5439-48.
2. Nonami A, et al. Blood. 2015 May 14;125(20):3133-43.
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