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Chemical Structure : GNF2133
Catalog No.: PC-72351Not For Human Use, Lab Use Only.
GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β.
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GNF2133 (GNF-2133) is a potent and selective DYRK1A inhibitor with IC50 of 6 nM, without inhibitory effect on GSK3β.
In vitro, GNF2133 is able to proliferate both rodent and human β-cells.
In vivo, GNF2133 demonstrated significant dose-dependent glucose disposal capacity and insulin secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) challenge in rat insulin promoter and diphtheria toxin A (RIP-DTA) mice.
| M.Wt | 434.544 | |
| Formula | C24H30N6O2 | |
| Appearance | Solid | |
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1. Yahu A Liu, et al. J Med Chem. 2020 Mar 26;63(6):2958-2973.
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