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Chemical Structure : GNF4877
CAS No.: 2041073-22-5
Catalog No.: PC-22435Not For Human Use, Lab Use Only.
GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GNF4877 is a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) with IC50 of 6 nM and 16 nM, respectively, has a synergistic effect enhancing β-cell proliferation.
GNF4877 induces primary human β-cell proliferation in vitro and in vivo. induced β-cell proliferation.
GNF4877 increases β-cell mass and insulin content and improves glycemic control in diabetic mice.
| M.Wt | 494.53 | |
| Formula | C25H27FN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(3-(3-Amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid |
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1. Liu YA, et al. ChemMedChem. 2020 Aug 19;15(16):1562-1570.
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