GNI-50 | NAMPT inhibitor | Probechem Biochemicals

Chemical Structure : GNI-50

GNI-50 (GNI50, NAMPT inhibitor)

Catalog No.: PC-73040Not For Human Use, Lab Use Only.

GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.

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Biological Activity

GNI-50 is a potent, selective Nampt inhibitor with enzyme IC50 of 7 nM, A2780 cellular IC50 of 32 nM.
GNI-50 showed excellent in vivo antitumor efficacy when dosed orally in an A2780 ovarian tumor xenograft model (TGI of 97% was observed on day 17).

Physicochemical Properties

M.Wt	402.469
Formula	C19H22N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)phenyl)-3-(pyridin-3-ylmethyl)urea

References

1. Zheng X, et al. J Med Chem. 2013 Jun 27;56(12):4921-37.

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GNI-50 (GNI50, NAMPT inhibitor)

Biological Activity

Physicochemical Properties

References

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