GNX-865 | mPTP inhibitor | Probechem Biochemicals

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Chemical Structure : GNX-865

GNX-865 (GNX865)

Catalog No.: PC-62131Not For Human Use, Lab Use Only.

GNX-865 is a potent mitochondrial permeability transition pore (mPTP) inhibitor with EC50 of 105 uM (mitochondrial swelling).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GNX-865 is a potent mitochondrial permeability transition pore (mPTP) inhibitor with EC50 of 105 uM (mitochondrial swelling).
GNX-865 attenuates opening of the mPTP and limits reperfusion injury in a rabbit model of acute myocardial infarction.

Physicochemical Properties

M.Wt	303.742
Formula	C16H14ClNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(3-Chloro-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-acrylamide

References

1. Fancelli D, et al. J Med Chem. 2014 Jun 26;57(12):5333-47.

2. Roy S, et al. ChemMedChem. 2015 Oct;10(10):1655-71.

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GNX-865 (GNX865)

Biological Activity

Physicochemical Properties

References

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