GPR119 agonist K-833

Chemical Structure : GPR119 agonist K-833

Catalog No.: PC-25131Not For Human Use, Lab Use Only.

GPR119 agonist K-833 is a potent GPR119 agonist with EC50 of 39.8 nM (hGPR119), potentiates GPR40 full agonist AM-5262 robust GPR40-mediated effects, leading to synergistic increases in GLP-1 levels.

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Biological Activity

GPR119 agonist K-833 is a potent GPR119 agonist with EC50 of 39.8 nM (hGPR119), potentiates GPR40 full agonist AM-5262 robust GPR40-mediated effects, leading to synergistic increases in GLP-1 levels.

Physicochemical Properties

M.Wt	640.15
Formula	C30H43ClFN5O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(3-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)propoxy)-2-fluorophenyl)-1-(3-((((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)methyl)azetidin-1-yl)ethan-1-one

References

1. Moyes CR, et al. J Med Chem. 2025 Jul 24. doi: 10.1021/acs.jmedchem.5c01030.

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