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Chemical Structure : GPR120 agonist 1
CAS No.: 1599477-75-4
Catalog No.: PC-42400Not For Human Use, Lab Use Only.
GPR120 agonist 1 is a potent, fully selective, orally available GPR120 (FFA4) agonist with pEC50 of 7.62.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $478 | In stock | |
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GPR120 agonist 1 is a potent, fully selective, orally available GPR120 (FFA4) agonist with pEC50 of 7.62.
GPR120 shows with negligible activity towards GPR40.
GPR120 recruits β-arrestin-2 in both human and mouse Gpr120 expressing cells with EC50 of ~0.35 uM, produces concentration dependent increases in IP3 production.
GPR120 exerts potent anti-inflammatory effects on macrophages in vitro and in obese mice in vivo, causes improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity and decreased hepatic steatosis.
| M.Wt | 405.8390296 | |
| Formula | C19H23ClF3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Azaspiro[5.5]undecane-9-acetic acid, 3-[2-chloro-5-(trifluoromethoxy)phenyl]- |
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1. Oh DY, et al. Nat Med. 2014 Aug;20(8):942-7.
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