Catalog No.: PC-62255Not For Human Use, Lab Use Only.
GPR39 agonist 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels.
GPR39 agonist 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels.
GPR39 agonist 3 activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling.
GPR39 agonist 3 is a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.
