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Chemical Structure : GPR39 agonist 7
Catalog No.: PC-62256Not For Human Use, Lab Use Only.
GPR39 agonist 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels.
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GPR39 agonist 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels.
GPR39 agonist 7 activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling.
GPR39 agonist 7 is a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.
| M.Wt | 604.774 | |
| Formula | C31H40N8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bassilana F, et al. Nat Chem Biol. 2014 May;10(5):343-9.
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