GPR40 agonist AP8

Chemical Structure : GPR40 agonist AP8

Catalog No.: PC-20870Not For Human Use, Lab Use Only.

GPR40 agonist AP8 is a potent, selective, full allosteric agonist (AgoPAM) of GPR40 with EC50 of 0.6 nM, Emax=268%.

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Biological Activity

GPR40 agonist AP8 is a potent, selective, full allosteric agonist (AgoPAM) of GPR40 with EC50 of 0.6 nM, Emax=268%.

M.Wt	549.61
Formula	C30H35F4NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R)-3-cyclopropyl-3-((R)-2-(1-((S)-1-(5-fluoro-2-(trifluoromethoxy)phenyl)ethyl)piperidin-4-yl)chroman-7-yl)-2-methylpropanoic acid

1. Jun Lu, et al. GPR40 agonist AP8, Nat Struct Mol Biol . 2017 Jul;24(7):570-577.