GPR40 agonist K-757

Chemical Structure : GPR40 agonist K-757

Catalog No.: PC-25130Not For Human Use, Lab Use Only.

GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40).

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Biological Activity

GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40).
K-757 is selective against panel of 80 enzymes, receptors, and ion channels.
K-757 (10 mg/kg) elicited GLP-1 secretion in crypt cultures derived from wild-type mice but not from GPR40 knockout mice, induced secretion of both GLP-1 and PYY in human crypts.

Physicochemical Properties

M.Wt	541.71
Formula	C32H48NO4P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-2-Cyclopropyl-2-(3-((1-(2-(4,4-dimethylpentyl)-5-methoxyphenyl)piperidin-4-yl)methoxy)phenyl)ethyl)(methyl)phosphinic Acid

References

1. Moyes CR, et al. J Med Chem. 2025 Jul 24. doi: 10.1021/acs.jmedchem.5c01030.

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