GPR4 antagonist 39c

Chemical Structure : GPR4 antagonist 39c

Catalog No.: PC-20836Not For Human Use, Lab Use Only.

GPR4 antagonist 39c is a potent and orally active GPR4 antagonist with IC50 of 110 nM.

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Biological Activity

GPR4 antagonist 39c is a potent and orally active GPR4 antagonist with IC50 of 110 nM.
GPR4 antagonist 39c shows potent cellular activity and is efficacious in animal models of angiogenesis, inflammation and pain.

Physicochemical Properties

M.Wt	431.63
Formula	C27H37N5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	CC1=C2C(N(CC3=CC=C(/C=C/CN4CCN(C(C)C)CC4)C=C3)C(CC)=N2)=NC(C)=C1

References

1. Wolfgang Miltz, et al. Bioorg Med Chem. 2017 Aug 15;25(16):4512-4525.

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