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Chemical Structure : GPR4 antagonist 3b
Catalog No.: PC-61082Not For Human Use, Lab Use Only.
GPR4 antagonist 3b is the first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM).
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GPR4 antagonist 3b is the first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM).
GPR4 antagonist 3b effectively prolongs life in the mouse myocardial infarction model in vivo, and GPR4 antagonist 3b is a very effective tool for investigating the physiologic and pharmacologic roles of GPR4.
| M.Wt | 479.672 | |
| Formula | C31H37N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fukuda H, et al. ACS Med Chem Lett. 2016 Feb 24;7(5):493-7.
2. Tobo A, et al. PLoS One. 2015 Jun 12;10(6):e0129334.
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