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GPX-150

Chemical Structure : GPX-150

CAS No.: 236095-29-7

GPX-150 (GPX150, CNDO-101, DIDOX, 5-imino-13-deoxy-doxorubicin)

Catalog No.: PC-60558Not For Human Use, Lab Use Only.

GPX-150 (DIDOX, 5-imino-13-deoxy-doxorubicin) is a doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GPX-150 (DIDOX, 5-imino-13-deoxy-doxorubicin) is a doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM.

    Physicochemical Properties

    M.Wt 528.558
    Formula C27H32N2O9
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (8R,10S)-10-(((2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-7,9,10,12-tetrahydrotetracen-5(8H)-one

    References

    1. Holstein SA, et al. Invest New Drugs. 2015 Jun;33(3):594-602.

    2. Frank NE, et al. Invest New Drugs. 2016 Dec;34(6):693-700.

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