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Chemical Structure : GR127935
Catalog No.: PC-61865Not For Human Use, Lab Use Only.
GR127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
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GR127935 is a potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor.
GR127935 displays >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types.
GR127935 blocks porcine carotid vascular response to sumatriptan in vivo; orally bioavailable and centrally active.
| M.Wt | 497.587 | |
| Formula | C29H31N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Clitherow JW, et al. J Med Chem. 1994 Jul 22;37(15):2253-7.
2. Knobelman DA, et al. J Pharmacol Exp Ther. 2001 Sep;298(3):1083-91.
3. De Vries P, et al. Br J Pharmacol. 1996 May;118(1):85-92.
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