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Chemical Structure : GR159897
Catalog No.: PC-70192Not For Human Use, Lab Use Only.
GR159897 is a potent non-peptide antagonist of tachykinin NK2 receptor with pKi of 9.5 in CHO cells.
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GR159897 is a potent non-peptide antagonist of tachykinin NK2 receptor with pKi of 9.5 in CHO cells.
GR159897 competitively antagonises the contractions induced by GR64349 in guinea-pig trachea (pA2 8.7).
GR159897 has negligible activity at human NK1 (pKi<5).
GR159897 potently antagonises bronchoconstriction induced by GR6434 in the anaesthetised guinea-pig.
GR159897 shows anxiolytic effects in animal models.
| M.Wt | 414.535 | |
| Formula | C23H27FN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Beresford IJ, et al. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8.
2. Walsh DM, et al. Psychopharmacology (Berl). 1995 Sep;121(2):186-91.
3. Advenier C. Can J Physiol Pharmacol. 1995 Jul;73(7):878-84.
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