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Chemical Structure : GRA Ex-25
CAS No.: 307983-31-9
Catalog No.: PC-45839Not For Human Use, Lab Use Only.
GRA Ex-25 is a potent glucagon receptor inhibitor with IC50 of 56 and 55 nM for rat and human glucagon receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $78 | In stock | |
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GRA Ex-25 is a potent glucagon receptor inhibitor with IC50 of 56 and 55 nM for rat and human glucagon receptors.
GRA Ex-25 binds to human glucagon receptor with Ki of 63 nM, moderately inhibits glucagon induced adenylate cyclase (Ki=254 nM).
GRA Ex-25 significantly reduces blood glucose caused by exogenous administration of glucagon in rat model (3 mg/kg, i.v.).
| M.Wt | 563.6085 | |
| Formula | C29H36F3N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
β-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]- |
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1. Kurukulasuriya R, et al. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50.
2. Lau J, et al. J Med Chem. 2007 Jan 11;50(1):113-28.
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