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GRK6 inhibitor 18

Chemical Structure : GRK6 inhibitor 18

CAS No.: 2677786-61-5

GRK6 inhibitor 18

Catalog No.: PC-72421Not For Human Use, Lab Use Only.

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.
GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases.
GRK6 inhibitor 18 has potent cellular target engagement and antiproliferative activity against MM cells (IC50=0.4-0.46 uM) and is synergistic with bortezomib.

Physicochemical Properties

M.Wt 438.916
Formula C22H23ClN6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. David E Uehling, et al. J Med Chem. 2021 Aug 12;64(15):11129-11147.

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