GRK6 inhibitor 18

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Chemical Structure : GRK6 inhibitor 18

CAS No.: 2677786-61-5

Catalog No.: PC-72421Not For Human Use, Lab Use Only.

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$348	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.
GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases.
GRK6 inhibitor 18 has potent cellular target engagement and antiproliferative activity against MM cells (IC50=0.4-0.46 uM) and is synergistic with bortezomib.

Physicochemical Properties

M.Wt	438.916
Formula	C22H23ClN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility
Chemical Name/SMILES	N2-(4-chloro-2-methoxybenzyl)-N4-(5-ethyl-1H-pyrazol-3-yl)-5-methoxyquinazoline-2,4-diamine

References

1. David E Uehling, et al. J Med Chem. 2021 Aug 12;64(15):11129-11147.

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