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GRL-0617

Chemical Structure : GRL-0617

CAS No.: 1093070-16-6

GRL-0617 (GRL0617;GRL 0617)

Catalog No.: PC-70199Not For Human Use, Lab Use Only.

GRL-0617 (GRL0617) is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GRL-0617 (GRL0617) is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM.
GRL-0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 14.5 uM, has no associated cytotoxicity and no inhibition for host DUBs (human deubiquitinating enzymes HAUSP, USP18, UCH-L1, UCH-L3).

Physicochemical Properties

M.Wt 304.393
Formula C20H20N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide

References

1. Ratia K, et al. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

2. Chaudhuri R, et al. J Mol Biol. 2011 Nov 25;414(2):272-88.

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