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Chemical Structure : GS-248
Catalog No.: PC-49465Not For Human Use, Lab Use Only.
Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA).
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Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA).
GS-248 displays 1000-fold more potent than that of celecoxib.
GS-248 shows no cross reactivity with COX1 or COX2.
GS-248 displays IC50 values for human, dog, rat/mouse and minipig mPGES1 of 2.5, 1.3, > 1000 and 23 nM, respectively.
GS-248 shows significant activity comparable to celecoxib and indomethacin in mice.
| M.Wt | 678.526 | |
| Formula | C30H34Cl2F5N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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