Catalog No.: PC-49465Not For Human Use, Lab Use Only.
Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA).
Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA).
GS-248 displays 1000-fold more potent than that of celecoxib.
GS-248 shows no cross reactivity with COX1 or COX2.
GS-248 displays IC50 values for human, dog, rat/mouse and minipig mPGES1 of 2.5, 1.3, > 1000 and 23 nM, respectively.
GS-248 shows significant activity comparable to celecoxib and indomethacin in mice.
