GS-462808 |CAS:1354198-41-6 Probechem Biochemicals

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Chemical Structure : GS-462808

GS-462808 (GS462808)

Catalog No.: PC-62718Not For Human Use, Lab Use Only.

GS-462808 is a potent Late INa current inhibitor of the cardiac Nav1.5 channel with IC50 of 1.33 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GS-462808 is a potent Late INa current inhibitor of the cardiac Nav1.5 channel with IC50 of 1.33 uM.
GS-462808 has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967.
GS-462808 shows improved anti-ischemic potency relative to ranolazine.

Physicochemical Properties

M.Wt	391.31
Formula	C17H12F3N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

References

1. Koltun DO, et al. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-11.

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GS-462808 (GS462808)

Biological Activity

Physicochemical Properties

References

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