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Chemical Structure : GS-462808
Catalog No.: PC-62718Not For Human Use, Lab Use Only.
GS-462808 is a potent Late INa current inhibitor of the cardiac Nav1.5 channel with IC50 of 1.33 uM.
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GS-462808 is a potent Late INa current inhibitor of the cardiac Nav1.5 channel with IC50 of 1.33 uM.
GS-462808 has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967.
GS-462808 shows improved anti-ischemic potency relative to ranolazine.
| M.Wt | 391.31 | |
| Formula | C17H12F3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Koltun DO, et al. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-11.
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