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Chemical Structure : GS-5759
Catalog No.: PC-60211Not For Human Use, Lab Use Only.
GS-5759 is a novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM).
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GS-5759 is a novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM).
GS-5759 inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM).
GS-5759 also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts.
| M.Wt | 850.95 | |
| Formula | C47H42N6O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tannheimer SL, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):85-93.
2. Joshi T, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):324-340.
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