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GS-6671

Chemical Structure : GS-6671

CAS No.: 2160563-83-5

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GS-6671 (GS6671)

Catalog No.: PC-22187Not For Human Use, Lab Use Only.

GS-6671 is a potent, orally bioavailable inhibitor of HBV surface antigen (HBsAg) with EC50 of 5.8 nM in HepG2-NTCP assays, via inhibition of the human poly(A) polymerases PAPD5/7, promoting destabilization and degradation of HBV mRNA.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GS-6671 is a potent, orally bioavailable inhibitor of HBV surface antigen (HBsAg) with EC50 of 5.8 nM in HepG2-NTCP assays, via inhibition of the human poly(A) polymerases PAPD5/7, promoting destabilization and degradation of HBV mRNA.

Physicochemical Properties

M.Wt 420.89
Formula C21H25ClN2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(tert-butyl)-10-chloro-9-(3-methoxypropoxy)-2-oxo-6,7-dihydro-2H-pyrido[2,1-a]phthalazine-3-carboxylic acid

References

1. Kato D, et al. ACS Med Chem Lett. 2024 Mar 22;15(4):546-554.

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