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Chemical Structure : GS-680
Catalog No.: PC-72971Not For Human Use, Lab Use Only.
GS-680 (GS680) is a novel selective and ATP-competitive CaMKII inhibitor with biochemical IC50 of 2.3 and 15.9 nM against CaMKIIδ and CaMKIIα, respectively.
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GS-680 (GS680) is a novel selective and ATP-competitive CaMKII inhibitor with biochemical IC50 of 2.3 and 15.9 nM against CaMKIIδ and CaMKIIα, respectively.
GS-680 inhibited phospholamban phosphorylation in NRVM with an EC50 of 98.9 nM.
GS-680 inhibits premature atrial contractions.
GS-680 significantly reduced CaMKII autophosphorylation.
GS-680 inhibits pro-arrhythmic activity in human atrium and improves contractility in failing human ventricle.
| M.Wt | 390.465 | |
| Formula | C20H18N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. S Lebek, et al. J Mol Cell Cardiol. 2018 May;118:159-168.
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