Catalog No.: PC-43116Not For Human Use, Lab Use Only.
GS-458967 (GS967) is a potent, selective inhibitor of cardiac late sodium current (late INa), inhibits TX-II-induced late INa in ventricular myocytes and isolated hearts with IC50 of 0.13 and 0.21 uM, respectively.
GS-458967 (GS967) is a potent, selective inhibitor of cardiac late sodium current (late INa, Nav1.5), inhibits TX-II-induced late INa in ventricular myocytes and isolated hearts with IC50 of 0.13 and 0.21 uM, respectively.
GS967 displays >76-fold selectivity over inhibition of IKr (IC50>10 uM).
GS967 prevents and reverses proarrhythmic effects of the late I(Na) enhancer ATX-II and the I(Kr) inhibitor E-4031 in isolated ventricular myocytes and hearts.
GS967 significantly attenuates the proarrhythmic effects of methoxamine+clofilium and suppresses ischemia-induced arrhythmias in vivo.
