GSK-114 |CAS:1301761-96-5 Probechem Biochemicals

Chemical Structure : GSK-114

CAS No.: 1301761-96-5

GSK-114 (GSK114)

Catalog No.: PC-62726Not For Human Use, Lab Use Only.

GSK-114 is a potent, selective TNNI3K (TNNI3 Interacting Kinase) inhibitor with IC50 of 25 nM, dispalys 40-fold over B-Raf, exceptional broad spectrum kinase selectivity (IC50>1,000 nM, 99% of kinases, 291/294).

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$348	In stock
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Biological Activity

GSK-114 is a potent, selective TNNI3K (TNNI3 Interacting Kinase) inhibitor with IC50 of 25 nM, dispalys 40-fold over B-Raf, exceptional broad spectrum kinase selectivity (IC50>1,000 nM, 99% of kinases, 291/294).
GSK-114 has adequate oral exposure to enable its use in cellular and in vivo studies.

Physicochemical Properties

M.Wt	417.484
Formula	C19H23N5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide

References

1. Lawhorn BG, et al. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3355-8.

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GSK-114 (GSK114)

Biological Activity

Physicochemical Properties

References

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