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GSK-2269557

Chemical Structure : GSK-2269557

CAS No.: 1254036-71-9

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GSK-2269557 (GSK2269557;Nemiralisib)

Catalog No.: PC-45643Not For Human Use, Lab Use Only.

Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).

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25 mg $258 In stock
50 mg $438 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).
Nemiralisib (GSK-2269557) displays >1000 fold selectivity versus other PI3K isoforms.
Nemiralisib (GSK-2269557) inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.2 and 8.1, respectively, in a human lung parenchyma assay.
Nemiralisib (GSK-2269557) shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=67ug/kg).

Physicochemical Properties

M.Wt 440.5401
Formula C26H28N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-

References

1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.

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