Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-PI3K-GSK-2269557
GSK-2269557

Chemical Structure : GSK-2269557

CAS No.: 1254036-71-9

Add to Favorites

GSK-2269557 (GSK2269557;Nemiralisib)

Catalog No.: PC-45643Not For Human Use, Lab Use Only.

Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).

Packing Price Stock Quantity
10 mg $148 In stock
25 mg $258 In stock
50 mg $438 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nemiralisib (GSK-2269557) is a highly potent and selective inhibitor of PI3Kδ (pKi=9.9).
Nemiralisib (GSK-2269557) displays >1000 fold selectivity versus other PI3K isoforms.
Nemiralisib (GSK-2269557) inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.2 and 8.1, respectively, in a human lung parenchyma assay.
Nemiralisib (GSK-2269557) shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=67ug/kg).

Physicochemical Properties

M.Wt 440.5401
Formula C26H28N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]-

References

1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: