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GSK-2292767

Chemical Structure : GSK-2292767

CAS No.: 1254036-66-2

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GSK-2292767 (GSK2292767)

Catalog No.: PC-70090Not For Human Use, Lab Use Only.

GSK-2292767 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSK-2292767 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).
    GSK-2292767 displays >1,000 fold selectivity versus others PI3K isoforms.
    GSK-2292767 inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.7 and 8.5, respectively, in a human lung parenchyma assay.
    GSK-2292767 shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=35 ug/kg).

    Physicochemical Properties

    M.Wt 512.58
    Formula C24H28N6O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide

    References

    1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.

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