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Chemical Structure : GSK-2336805
Catalog No.: PC-63396Not For Human Use, Lab Use Only.
GSK-2336805 (JNJ-56914845) is a novel potent HCV NS5A inhibitor with multigenotype activity, has EC50s of 58.5, 7.4, and 53.8 pM on genotype 1a (H77), genotype 1b (Con-1 ET), and genotype 2a (JFH-1) replicon cells.
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GSK-2336805 (JNJ-56914845) is a novel potent HCV NS5A inhibitor with multigenotype activity, has EC50s of 58.5, 7.4, and 53.8 pM on genotype 1a (H77), genotype 1b (Con-1 ET), and genotype 2a (JFH-1) replicon cells; shows an average EC50 of 63.7 pM on genotype 2a Jc1 virus, inhibits the HCV replication cycle and production of virus; retains activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6.
HCV Infection
Phase 2 Clinical
| M.Wt | 796.926 | |
| Formula | C42H52N8O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Walker J, et al. Antimicrob Agents Chemother. 2014;58(1):38-47.
2. Kazmierski WM, et al. J Med Chem. 2014 Mar 13;57(5):2058-73.
3. Bourgeois S, et al. BMC Gastroenterol. 2017 Feb 10;17(1):26.
4. Wilfret DA, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):5037-44.
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