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GSK-2485852

Chemical Structure : GSK-2485852

CAS No.: 1331942-30-3

GSK-2485852 (GSK2485852;GSK 2485852;GSK-5852;GSK 5852;GSK5852)

Catalog No.: PC-60428Not For Human Use, Lab Use Only.

GSK-2485852 (GSK2485852, GSK5852) is a highly potent, selective HCV NS5B polymerase inhibitor with IC50 of 3.0 and 1.6 nM for HCV genotypes 1a and 1b in replicon assay, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSK-2485852 (GSK2485852, GSK5852) is a highly potent, selective HCV NS5B polymerase inhibitor with IC50 of 3.0 and 1.6 nM for HCV genotypes 1a and 1b in replicon assay, respectively; displays an excellent resistance profile and shows a <5-fold potency loss across the clinically important NS5B resistance mutations P495L, M423T, C316Y, and Y448H; targets NNI palm site 2 of NS5B and inhibits all HCV genotypes.

    HCV Infection

    Phase 1 Clinical

    Physicochemical Properties

    M.Wt 554.3718
    Formula C27H25BF2N2O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    B-[4-[[[5-Cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-6-benzofuranyl](methylsulfonyl)amino]methyl]-2-fluorophenyl]boronic acid

    References

    1. Voitenleitner C, et al. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24.

    2. Wilfret DA, et al. Clin Pharmacol Drug Dev. 2014 Nov;3(6):439-48.

    3, Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.

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