GSK-2878175 (GSK8175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM
GSK-2878175 exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.
GSK-2878175 displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.
