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GSK-2878175

Chemical Structure : GSK-2878175

CAS No.: 1423007-82-2

GSK-2878175 (GSK2878175;GSK8175;GSK-175;GSK-175A)

Catalog No.: PC-63383Not For Human Use, Lab Use Only.

GSK-2878175 (GSK8175, GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B palm polymerase inhibitor with EC50 of 0.4-9.7 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM; exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons, displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.

HCV Infection

Phase 2 Clinical

Physicochemical Properties

M.Wt 568.807
Formula C27H23BClFN2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-[N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

References

1. Gardner SD, et al. J Viral Hepat. 2018 Jan;25(1):19-27.

2. Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.

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