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Chemical Structure : GSK-481
CAS No.: 1622849-58-4
Catalog No.: PC-42065Not For Human Use, Lab Use Only.
GSK-481 (GSK481) is a highly potent, monokinase selective and ATP-competitive inhibitor of RIP1 kinase (RIPK1) with biochemical IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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GSK-481 (GSK481) is a highly potent, monokinase selective and ATP-competitive inhibitor of RIP1 kinase (RIPK1) with biochemical IC50 of 10 nM.
GSK-481 displays complete specificity for RIP1 kinase over a panel of 456 kinases.
GSK-481 exhibits excellent translation in the U937 cellular assay with IC50 of 10 nM, demonstrates significant blockage of the induced RIP1 autophosphorylation at Ser166 in HT29 cells.
GSK-481 possesses good pharmacokinetic profiles in rodents.
| M.Wt | 377.3932 | |
| Formula | C21H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
3-Isoxazolecarboxamide, 5-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]- |
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1. Harris PA, et al. J Med Chem. 2016 Mar 10;59(5):2163-78.
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