Catalog No.: PC-45779Not For Human Use, Lab Use Only.
GSK-137647 (GSK-137647A) is a potent, selective GPR120 (FFA4) agonist with pEC50 of 6.3, >100-fold selectivity over the FFA1, FFA2, and FFA3 receptors.
GSK137647A (GSK137647) is a potent, selective GPR120 (FFA4) agonist with pEC50 of 6.3, >100-fold selectivity over the FFA1, FFA2, and FFA3 receptors.
GSK137647A augments insulin release from rat/mouse islets and rat β-cell line INS-1E.
GSK137647A attenuats both basal and LPS-induced production of IL-6 and CCL2, reduces the phosphorylation of IκBα and nuclear translocation of NFkappa-B p65 subunit (p65) in 3T3-L1 adipocytes.
GSK137647A improves postprandial hyperglycaemia of diabetic mice.
