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Chemical Structure : GSK137647A
CAS No.: 349085-82-1
Catalog No.: PC-45779Not For Human Use, Lab Use Only.
GSK-137647 (GSK-137647A) is a potent, selective GPR120 (FFA4) agonist with pEC50 of 6.3, >100-fold selectivity over the FFA1, FFA2, and FFA3 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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GSK137647A (GSK137647) is a potent, selective GPR120 (FFA4) agonist with pEC50 of 6.3, >100-fold selectivity over the FFA1, FFA2, and FFA3 receptors.
GSK137647A augments insulin release from rat/mouse islets and rat β-cell line INS-1E.
GSK137647A attenuats both basal and LPS-induced production of IL-6 and CCL2, reduces the phosphorylation of IκBα and nuclear translocation of NFkappa-B p65 subunit (p65) in 3T3-L1 adipocytes.
GSK137647A improves postprandial hyperglycaemia of diabetic mice.
| M.Wt | 305.392 | |
| Formula | C16H19NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL; H2O: < 0.06 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
Benzenesulfonamide,4-methoxy-N-(2,4,6-trimethylphenyl)- |
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1. Sparks SM, et al. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3.
2. Zhang D, et al. Clin Sci (Lond). 2017 Feb 1;131(3):247-260.
3. Hasan AU, et al. Biochem Biophys Res Commun. 2017 Apr 22;486(1):76-82.
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